One of the things I loved about this book, was the detailed explanations of vast amounts of published research --much of it I was not familiar with. For example in the section about IGF-1 and Heart Disease, he not only explains how those with the highest blood levels of this growth hormone have increased cardiovascular mortality (and consumption of animal protein is established to increase blood levels of this hormone) but then goes on to describe a 2014 study that added more clarity by comparing low glycemic high in animal protein (low-carb/high protein) with diets low in both refined carbs and animal protein. 6000 people followed for 18 years found a four fold increase in cancer mortality and 75% increase in all-cause mortality. Researchers further isolated the negative effects of high protein as being ONLY from animal protein, not plant protein.
Other sections of the book thoroughly explain popular headlines that have confused many about the contributions of meat, cheese and butter to heart disease, by showing reductions of specific biomarkers when these foods are substituted for refined carbohydrates. It turns out that BOTH refined carbs (like sugar and white flour) and animal foods are profoundly harmful -- and substituting one for the other can make certain markers improve -- but not a single study has demonstrated such changes can morbidity or mortality long term -- while the plant-based diets have.
Many other subjects are addressed in a similarly comprehensive and clear way and always well-referenced. For example he discusses salt and stroke risk, summarizes the pros and cons of various cardio protective diets, the impact of saturated fats on inflammation, the risks and overselling of statin drugs, to name just a few. In addition his dietary recommendations are thoroughly explained -- along with the justifications and the book includes a large section of recipes. Including the index, there are 430 pages -- a real bargain at $29.00 when you consider the cost of the book against just a single month's prescription of drugs that can probably be avoided by reading this book.
If you know someone motivated to avoid being cut open or placed on powerful drugs for the rest of their life, this is THE book to have them read!