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Flu Vaccine -- A Critical Look at the Evidence

1/25/2017

2 Comments

 
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About 20 years ago as the new mother of an infant, I spent some time in Australia.  Just prior to this I had left my job as a microbiologist for a large multi-national pharmaceutical company and was deeply interested in the conversation that was happening at that time around the issue of vaccines.  I knew that vaccines were one of the greatest success stories of modern medicine, but I had a friend who had not had as much science education and she did not share my view. Out of concern for her children, I decided to delve  into the topic -- so that I could educate my friend and shine a light on the nonsense that she had fallen prey to.

Compared to now, it was a very different atmosphere in terms of being able to discuss vaccines and vaccine policy.  Paul Offit was not yet the poster boy for mandatory vaccination, and one could actually ask questions in public arenas seeking to understand the real evidence regarding both the safety and efficacy of individual vaccines, without being vilified as, "Anti-vaccine," or "Anti-science."  Today those labels are used to immediately shut down meaningful discussions.   Additionally, doctors and scientists who advocated informed consumer choice for parents, were not subject to well-orchestrated attacks from those seeking to revoke their medical licenses or discredit them as professionals.  I spent a lot of time as a new mother at the medical library researching vaccines and then calling the CDC over and over, as well as calling my old immunology professors to discuss my findings, and try to make sense of everything I was learning.

Also at that time, the vaccine schedule was not as extensive and did not include the chickenpox, or HPV vaccines -- both of which may actually have negative public health outcomes as a growing body of evidence suggests.   For example while we've seen a decrease in Chickenpox cases since the introduction of the chickenpox vaccine, shingles has increased significantly -- which is concerning because it's a  more dangerous and more expensive disease to treat. This is consistent with mathematical modeling done around the time of licensure that predicted increases in shingles might result from use of  the chickenpox vaccine.   Meanwhile the HPV vaccine has misled young women into thinking that they no longer need to get PAP smears, which when used regularly, have been shown to be nearly 100% effective in preventing cervical cancer, while the Gardasil vaccine is only about 40% effective at this, and there is no data showing that protection lasts even 15 years -- long enough to protect the pre-pubescent girls it is being given to at the time they really need it.  Newer studies now suggest that the introduction and marketing of Gardasil, will result in increases in cervical cancer in industrialized nations as compared to what we had prior to use of this vaccine.  However, due to the intensely charged rhetoric, and the advertising purchasing power of pharma which influences the types of stories the media covers, few people know that these two vaccines actually have no science to support their public health benefit.  However, a law passed in 1986 gave vaccine manufactures and doctors immunity from liability should anyone be harmed by any of the vaccines on the federal pediatric vaccine schedule and that has drastically impacted the economics around vaccinations -- and thus our public policy. (keep reading....continues after photo...)
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When I arrived in Australia after I had started researching vaccines  here in America, I learned about some of the differences in their health care system.  But the most interesting thing that I noticed while in Australia in the mid 1990s, was the very different view that medical personnel there had about the flu vaccine, as compared to their American counterparts.  In America, pharmaceutical PR had already done a superb job of influencing  doctors and policy makers with regards to the flu vaccine -- as most were enthusiastically endorsing it, even though there was almost no good research showing it's efficacy.  However, big pharma's  efforts with regard to promoting the flu vaccine had not yet saturated the land down under,  and this manifested in a very different view amongst health-care personnel there.   Over and over doctors, nurses and pharmacists there told me, "Well everybody knows that the flu vaccine is a joke."  On top of that I also learned that many people reported having had, "flu-like symptoms" following getting the flu vaccine  after not having had any flu-like symptoms for many years prior to being vaccinated. 

​Since it has been many years since I've been to Australia, I don't know what their attitude towards the flu vaccine is now, but in America, flu vaccines were and continue to be big business.  The World Health Organization  points out that vaccines are the fastest growing sector of the pharmaceutical industry, and they expect that next year in the U.S., sales of the influenza vaccine alone,  will be nearly 4 billion dollars.  No wonder we are inundated with advertising, and pressure from "community partners" to get our flu shot.   Like the ubiquitous, milk mustache campaigns trying to persuade us that dairy will improve our health, many have no idea how much science contradicts both of these marketing ploys.

The Cochrane Collaboration is a global independent network of researchers free from commercial sponsorship. They conduct and publish meta studies to help inform health decisions and are widely viewed as one of the least biased, evidenced-based sources of medical information.  In 2014 they did a review of influenza vaccines, (which I'd encourage you to actually read for yourself by clicking on that link) but here are a few things I screen shot from that document (below).  In a nutshell, this meta study, found a very small benefit of flu shots overall.   But since as Cochrane points out they were unable to assess the real impact of bias on this subject, it is possible that even the small benefit they found is over-optimistic (keep in mind too that most published studies are designed and funded by those who stand to profit from sales of flu vaccines.   For a long time, we've had plenty of evidence that when studies don't turn out in ways that supports pharma's sales -- that data never gets published -- it just disappears -- since those funding it often have researchers sign contracts to not publish any results without permission from the pharmaceutical company.)  It is also important to note that Cochrane said, "The Harms evidence base was limited." meaning that they were unable to accurately assess the risk-benefit of flu vaccines.  Below are screen shots from Cochrane's study....(keep scrolling down though I have even more to share!)
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​Then in  2015, The New England Journal of Medicine published a flu study that is featured prominently on the CDC's site HERE which purports to show that influenza vaccination makes one less likely to be hospitalized for pneumonia, if they do come down with the flu.  However,  I interpreted their data quite differently.   The study looked at  2767 people admitted to the hospital with Pneumonia and found that 162 of them had laboratory confirmed influenza, while 2605 did not.  It is worth pointing out that what most people think of as, "The Flu" is actually a set of symptoms such as a respiratory tract infection along with fever and aches and pains.  There are many other infections (including food-borne illness!)  that can have these symptoms, and more often than not what most people call, "The Flu" is NOT influenza. I have never seen evidence, nor even a theoretical basis to suggest that the influenza vaccine might prevent any of these other, "flu-like illnesses".  

Of the 2767 people who were hospitalized with pneumonia, 162 of them tested positive for influenza, leaving 2605 who were hospitalized for pneumonia  that was not caused by influenza.  The first thing I noticed when looking at this data was this:  Influenza looks to be a rather minor contributor to hospitalizations for pneumonia (since only about 6% of those with pneumonia were positive for influenza.)  That means most cases of Pneumonia severe enough to lead to hospitalization come from other causes -- including  "Influenza-like viruses" that the vaccine would not be expected to offer any protection against.

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But here is the bigger point I'd like to make.  The authors of this study suggest that their data show that influenza vaccination protected people who got influenza from going on to be hospitalized with pneumonia -- because only 17% of those positive for influenza had gotten the vaccine, compared to 29% of those who had other flu-like illnesses (and had gotten the flu vaccine. ) But is it not equally valid to suggest that perhaps these different numbers are not due to the flu vaccine affording protection from pneumonia -- but rather the fact that having had the vaccine actually increased the likelihood that if exposed to "flu like illnesses" one would go on to be hospitalized for pneumonia?  Just based upon the data in this paper aren't these two perspectives equally plausible explanations for the 17% versus 29%?

Given that people undergoing chemotherapy are known to be more vulnerable to infectious disease -- because we understand that exposure to toxic substances can negatively impact the the ability of the immune system to respond optimally to infections, is it not possible that injecting toxins like aluminum, formaldehyde and foreign proteins and other common vaccine components into the bloodstream might likewise make one more vulnerable to certain infectious diseases too?  This paper offers no evidence to support that my alternative interpretation is any less valid then the one that the authors of this study put forth.
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Furthermore, there is evidence that injections (like vaccines) can actually increase the odds that exposure to a vaccine during an epidemic can make a person more likely to experience more serious symptoms, (example: Polio Provocation) so it seems reasonable to me that something like that could be the explanation for the data presented in this study -- namely that getting an influenza vaccine, far from simply being ineffective, may actually increase one's odds of ending up in the hospital with pneumonia.  Again keep in mind -- that this study also shows that the majority of cases of people having what may seem like, "the flu", is not influenza -- and clearly that group is NOT benefited from the flu vaccine and may even be at greater harm.

Let me restate this another way: These data suggest that for most people influenza presents a very small risk that they will be hospitalized with pneumonia.  They are much more likely to  end up hospitalized with pneumonia from infections other then the influenza.  If they have gotten a flu vaccine and then get sick with something besides influenza, this study suggests that they will have an increased risk of being hospitalized with pneumonia.

Add to all this, evidence that US Flu Death Figures May be More PR than Science.  Barbara Loe Fisher has a nice article HERE explaining all of this too, with a lot more references to the peer-reviewed literature.  Even the CDC's  own surveillance data shows  that usually about 80-90% of what most people seek medical care for as, "The Flu" turns out, after laboratory testing to not be caused by the influenza virus.  You can read CDC's figures HERE.

I believe that each vaccine needs to be looked at carefully to see exactly what science exists to support its public health benefits.  Given that we have many examples of the pharmaceutical industry intentionally misleading the public regarding the safety or benefits of various prescription drugs (Vioxx being the first that comes to mind) Why should we expect these same players to suddenly be more ethical when it comes to vaccines, especially when they have extraordinary legal protections from liability should vaccines (unlike other pharmaceutical drugs) injure or kill anyone, and they have the US government mandating that many of us must purchase these products.  The economic incentives to overstate the benefits, and minimize, or even hide the risks appear to be far greater for vaccines than any other pharmaceutical products.  Given the fact that health care personnel are not trained to analyze health care policy, nor assess the risks and benefits of drugs, but instead to simply implement established guidelines, and the fact that drug manufacturers work extremely hard to influence both health care workers and policy makers, I encourage everyone to do their own research and critical thinking on this issue.

If you liked this, you might also enjoy my articles:

Why the Chickenpox Vaccine is Nuts!
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Vaxxed -- Watch it and Make up Your Own  Mind
2 Comments
ingri cassel link
1/29/2017 03:04:58 pm

Hi JoAnn,
It's nice to see more microbiologists questioning their training. Have you seen our section on NIH's Human Microbiome Project? See http://www.vaclib.org/intro/microbiome.htm or our flu index page?
http://www.vaclib.org/basic/fluindex.htm Dewey (webmaster) put together a presentation on a simple dissection of an influenza flu package insert -- and this is simply a sample since most of them read pretty much the same. http://www.vaclib.org/basic/pi/index.htm
I must say that we do not promote the idea of 'infectious' diseases since we understand how the body works and are clear that disease happens FIRST and the proliferation of associated microbes are SECOND. This is a difficult concept for most people but microbiologist Stefan Lanka is challenging these holy dogmas that BigPharma counts on everyone believing without question. See http://anonhq.com/anti-vaxxer-biologist-stefan-lanka-bets-100k-measles-isnt-virus-wins-german-federal-supreme-court/ Make sure you read the comment section to be clear about this case -- the entire comment section.... So, JoAnn -- keep researching and then you will come to the realization that microbes don't cause disease -- humans do.

Reply
JoAnn Farb
1/29/2017 03:26:21 pm

Thank you for taking the time to share your thoughts! I do not see the "germ theory" and the idea that, "disease happens first" as mutually exclusive --- I believe the evidence suggests that both host receptivity (shaped by diet, stress, toxins, genes etc) and the specific characteristics of individual pathogens (germs) together determine who will become ill and how serious it will be.

I look forward to exploring the links you have provided.

Thank you,
JoAnn

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